VES-LPHeader_1800.pngReflections of the Human Gut Microbiome in the Blood Metabolome

Alpha-diversity in the gut microbiome holds many clues to understanding human health. Now those clues are more accessible because Institute for Systems Biology (ISB) researchers can predict the diversity of an individual’s gut microbiome by examining metabolites in the blood.

By analyzing the de-identified multi-omic data from participants in a consumer scientific wellness program, researchers found that they can predict the health-associated alpha diversity of the gut microbiome by using a model trained on 40 circulating blood metabolites. Additionally, they can classify people with low gut diversity as being potentially susceptible to diseases like Clostridium difficile (C. diff) by using an 11-metabolite model.

Metabolomics was a key tool used by ISB researchers throughout their work. In a microscopic world, cells communicate with each other by speaking in small molecules, metabolomics allowed the researchers to listen to the language spoken by the microbiome to the body.

Join Sean Gibbons, Ph.D., Assistant Professor at ISB and a co-corresponding author on the paper, and Greg Michelotti, Ph.D., Scientific Director of Biology at Metabolon, for our webinar: Reflections of the Human Gut Microbiome in the Blood Metabolome. During this event, we will discuss the research behind this paper, and its important findings, including:

  • How gut microbiome diversity can be measured in the bloodstream
  • What is the optimal level of alpha-diversity to promote health
  • How obesity impacts the gut microbiome

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